Table 6.
Pharmacokinetic parameters following mangiferin administration (10, 30, and 100 mg/kg, intravenously) (± = 6).
| Parameters | 10 mg/kg | 30 mg/kg | 100 mg/kg |
|---|---|---|---|
| AUC (min mg/mL) | 122.9617.1 | 452.5639.8 | 2424.26196.7a |
| Half-life of slow distribution phase (t 1/2β) (min) | 28.563.5 | 35.063.5 | 47.864.1* 1/2,b |
| Steady-state volume of distribution (Vss) (L/kg) | 3.060.3 | 2.560.3 | 2.060.3 ss |
| Cl (mL/min/kg) | 90.161 2.6 | 69.166.5 | 43.264.3* |
| Mean residence time (min) | 35.062.52 | 35.962.8 | 45.864.8* |
AUC = area under the concentration-time curve; Cl = clearance.
* Denotes the, significantly different (p = 0.05) from the dose of 10 and 30 mg/kg (Student's t test) and SS denotes the steady-state.
a
Significantly different (p = 0.05) from the dose of 10 and 30 mg/kg (Student t test).