Table 8.

The main pharmacokinetic parameters of CXB after a single intravenous administration of 5.0 mg/kg CXB in six male rats.

Parameter	Value
Vc (L/kg)	2.60 ± 1.88
t1/2 pi (h)	0.109 ± 0.058
Half-life of rapid distribution phase (t1/2 α) (h)	0.503 ± 0.173
t1/2 β (h)	8.17 ± 0.99
K12 (1/h)	1.38 ± 1.36
k21 (1/h)	2.24 ± 1.77
k13 (1/h)	1.17 ± 0.178
k31 (1/h)	0.113 ± 0.021
k10 (1/h)	4.53 ± 1.65
Cl (L/kg/h)	9.52 ± 1.73
AUC0–t (ng h/mL)	566.0 ± 76.4
AUC0–∞ (ng h/mL)	583.1 ± 79.7

AUC = area under the concentration-time curve; Cl = clearance.