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Selected pharmacokinetics parameters of nobiletin in male Sprague Dawley rats following oral administration of nobiletin at 50 mg/kg (n = 3/time point).
| Parameters | Plasma | Brain |
|---|---|---|
| AUC(0–t) (μg·h/mL) | 7.49 | 20.66 |
| AUC(0–∞) (μg·h/mL) | 7.84 | 23.20 |
| Cmax (μg·h/mL) | 1.78 | 4.20 |
| Tmax (h) | 1.00 | 1. 00 |
| Kel (1/h) | 0.39 | 0.06 |
| t1/2 (h) | 1.80 | 11.42 |
AUC = area under the concentration-time curve; Cmax = peak plasma concentration; Tmax = time of peak plasma concentration; Kel = elimination rate constant.
