Table 6.
Diagnostic value of markers combinations (all markers in combination positive) in discrimination of malignant from benign thyroid lesions
| For malignancy | CD56&CK19 | CD56&HBME1 | CD56&Gal3 | CK19&HBME1 | CK19&Gal 3 | HBME1&Gal 3 | CD56&Gal 3&CK19 | HBME-1&Gale3&CK19 | CD56&Gal 3&HBME-1 | CD56&CK19&HBME-1 | CD56&CK19&HBME-1&Gal 3 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sensitivity | 50.82 % | 50.00 % | 52.46 % | 60.66 % | 68.03 % | 64.75 % | 45.90 % | 54.92 % | 45.08 % | 45.08 % | 40.16 % |
| Specificity | 94.94 % | 98.73 % | 97.47 % | 89.87 % | 88.61 % | 92.41 % | 97.47 % | 93.67 % | 98.73 % | 98.73 % | 98.73 % |
| Positive Likelihood Ratio | 10.04 | 39.5 | 20.72 | 5.99 | 5.97 | 8.53 | 18.13 | 8.68 | 35.61 | 35.61 | 31.73 |
| Negative Likelihood Ratio | 0.52 | 0.51 | 0.49 | 0.44 | 0.36 | 0.38 | 0.56 | 0.48 | 0.56 | 0.56 | 0.61 |
| Disease prevalence | 60.70 % | 60.70 % | 60.70 % | 60.70 % | 60.70 % | 60.70 % | 60.70 % | 60.70 % | 60.70 % | 60.70 % | 60.70 % |
| Positive Predictive Value | 93.94 % | 98.39 % | 96.97 % | 90.24 % | 90.22 % | 92.94 % | 96.55 % | 93.06 % | 98.21 % | 98.21 % | 98.00 % |
| Negative Predictive Value | 55.56 % | 56.12 % | 57.04 % | 59.66 % | 64.22 % | 62.93 % | 53.85 % | 57.36 % | 53.79 % | 53.79 % | 51.66 % |