Table 7.
Sensitivity and specificity values of different markers combinations for different combinations of PH entities
| All markers in combination were positive Sensitivity & Specificity for first in comparison | Malign Benign | PTC vs FA | FVPTC vs FA | FVPTC vs FTC | FTC vs FA | PTC vs non-tumor | HCC vs HCA | |
|---|---|---|---|---|---|---|---|---|
| CD56_CK19 | Sensitivity | 50.8 % | 65.5 % | 50.0 % | 50.0 % | 20.0 % | 65.5 % | 10.0 % |
| Specificity | 94.9 % | 100 % | 100.0 % | 85.7 % | 100.0 % | 92.9 % | 90.0 % | |
| CD56_HBME1 | Sensitivity | 50.0 % | 65.5 % | 55.0 % | 55.0 % | 13.3 % | 65.5 % | 10.0 % |
| Specificity | 98.7 % | 100 % | 100.0 % | 92.9 % | 100.0 % | 100.0 % | 90.0 % | |
| CD56_GAL3 | Sensitivity | 52.5 % | 69 % | 57.5 % | 57.5 % | 20.0 % | 69.0 % | 5.0 % |
| Specificity | 97.5 % | 100 % | 100.0 % | 85.7 % | 100.0 % | 97.6 % | 90.0 % | |
| HBME1_CK19 | Sensitivity | 60.7 % | 67.8 % | 52.5 % | 52.5 % | 20.0 % | 67.8 % | 60.0 % |
| Specificity | 89.9 % | 92.6 % | 92.6 % | 85.7 % | 92.6 % | 97.6 % | 50.0 % | |
| GAL3_HBME1 | Sensitivity | 64.8 % | 70.1 % | 60.0 % | 60.0 % | 20.0 % | 70.1 % | 75.0 % |
| Specificity | 92.4 % | 96.3 % | 96.3 % | 85.7 % | 96.3 % | 97.6 % | 60.0 % | |
| CK19_GAL3 | Sensitivity | 68.0 % | 78.2 % | 70.0 % | 70.0 % | 33.3 % | 78.2 % | 50.0 % |
| Specificity | 88.6 % | 88.9 % | 88.9 % | 71.4 % | 88.9 % | 92.9 % | 70.0 % | |
| CD56_CK19_HBME1 | Sensitivity | 45.1 % | 58.6 % | 45.0 % | 45.0 % | 13.3 % | 58.6 % | 10.0 % |
| Specificity | 98.7 % | 100 % | 100.0 % | 92.9 % | 100.0 % | 100.0 % | 90.0 % | |
| CD56_GAL3_HBME1 | Sensitivity | 45.1 % | 59.8 % | 50.0 % | 50.0 % | 13.3 % | 59.8 % | 5.0 % |
| Specificity | 98.7 % | 100 % | 100.0 % | 92.9 % | 100.0 % | 100.0 % | 90.0 % | |
| CD56_GAL3_CK19 | Sensitivity | 45.9 % | 59.8 % | 45.0 % | 45.0 % | 20.0 % | 59.8 % | 5.0 % |
| Specificity | 97.5 % | 100 % | 100.0 % | 85.7 % | 100.0 % | 97.6 % | 90.0 % | |
| HBME1_GAL3_CK19 | Sensitivity | 54.9 % | 62.1 % | 47.5 % | 47.5 % | 20.0 % | 62.1 % | 50.0 % |
| Specificity | 93.7 % | 96.3 % | 96.3 % | 85.7 % | 96.3 % | 97.6 % | 70.0 % | |
| CD56_HBME1_GAL3_CK19 | Sensitivity | 40.2 % | 52.9 % | 40.0 % | 40.0 % | 13.3 % | 52.9 % | 5.0 % |
| Specificity | 98.7 % | 100 % | 100.0 % | 92.9 % | 100.0 % | 100.0 % | 90.0 % | |
FA follicular adenoma, HA Hurthle cell adenoma, FTC follicular thyroid carcinoma, HCC Hurthle cell carcinoma, FVPTC folicular variant of papillary thyroid carcinoma, non-tumor (hyperplastic and colloid adenomas)