Table 1.
Subject clinical characteristics (infants included in final analyses; n=20)
| Infants without severe* IVH (n=20) | Infants with IVH (n=2) | ||
|---|---|---|---|
| Estimated gestational age at birth (weeks, mean ± sd) | 26.5 ± 1.7 | 24 (n/a) | 26 (n/a) |
| Median post-natal age at the time of study (days) | 2 [1-3] | 2 | 2 |
| Gender | |||
| Male | 6 | √ | √ |
| Female | 14 | ||
| Race | |||
| African American | 16 | √ | √ |
| Caucasian | 4 | ||
| Birthweight (grams, mean ± sd) | 930 ± 220 | ||
| CRIB scores (mean ± sd) | 3.6 ± 3.1 | 5 | 6 |
| Respiratory support at the time of study | |||
| None | 1 | ||
| Biphasic/NCPAP | 12 | ||
| SIMV | 7 | √ | √ |
| Inotropic support at the time of study | 0 | ||
| PDA (*none treated during study monitoring) | |||
| - Not clinically significant/never treated | 12 | ||
| - Treated with indomethacin alone | 5 | √ | √ |
| - Surgical ligation | 3 | ||
| Proven sepsis in the first 7 days of life | 0 | 0 | |
| Intraventricular hemorrhage | |||
| None | 19 | ||
| Grade I | 1 | ||
| Grade IV | 0 | √ | √ |
(CRIB = clinical risk index for babies, NCPAP = nasal continuous positive airway pressure, SIMV = synchronized intermittent mandatory ventilation, PDA = patent ductus arteriosus)
*
severe IVH is defined as grade III and/or grade IV IVH on either sides of the brain based on routine clinical ultrasounds within the first 7 days of life.