Association between neuropathy outcomes and pre-ART CD4 (per 100 higher cells/µL) |
Univariable Logistic Regression GEE Models |
|
At Baseline (pre-ART) |
Post-Baseline (post-ART) |
Post-Baseline (post-ART), HIV-RNA VL ≤ 50 cp/ml |
Dependent Variable: |
Odds Ratio (95%CI) |
p-value |
Odds Ratio (95%CI) |
p-value |
Odds Ratio (95%CI) |
p-value |
PN |
0.99 (0.90, 1.09) |
0.85 |
0.93 (0.89, 0.98) |
0.01 |
0.94 (0.88, 0.99) |
0.01 |
SPN |
0.69 (0.52, 0.91) |
0.01 |
0.94 (0.86, 1.02) |
0.13 |
0.93 (0.85, 1.02) |
0.13 |
Painful neuropathy |
0.75 (0.52, 1.08) |
0.12 |
0.95 (0.85, 1.05) |
0.29 |
0.95 (0.85, 1.06) |
0.33 |
Loss of vibration (Sign) |
0.90 (0.79, 1.04) |
0.15 |
0.92 (0.87, 0.97) |
0.003 |
0.91 (0.85, 0.97) |
0.002 |
Absent reflexes (Sign) |
1.01 (0.91, 1.12) |
0.85 |
0.94 (0.88, 0.99) |
0.02 |
0.94 (0.88, 1.00) |
0.04 |
Loss of vibration and reflexes (Sign) |
0.88 (0.72, 1.07) |
0.19 |
0.89 (0.82, 0.97) |
0.003 |
0.86 (0.79, 0.95) |
<.001 |
Pain (Symptom) |
0.94 (0.80, 1.12) |
0.50 |
0.98 (0.91, 1.05) |
0.57 |
0.98 (0.90, 1.06) |
0.62 |
Symptomatic (Symptom) |
0.88 (0.77, 1.01) |
0.07 |
0.97 (0.91, 1.03) |
0.30 |
0.97 (0.91, 1.03) |
0.31 |
Pins and needles (Symptom) |
0.83 (0.67, 1.02) |
0.07 |
0.98 (0.91, 1.06) |
0.62 |
0.97 (0.89, 1.05) |
0.39 |
Numbness (Symptom) |
0.80 (0.65, 0.98) |
0.03 |
0.92 (0.84, 0.99) |
0.03 |
0.91 (0.83, 0.99) |
0.02 |
Multivariable Logistic Regression GEE Models |
|
At Baseline (pre-ART) |
Post-Baseline (post-ART) |
Post-Baseline (post-ART), HIV-RNA VL ≤ 50 cp/ml |
Dependent Variable: |
Odds Ratio (95%CI) |
p-value |
Odds Ratio (95%CI) |
p-value |
Odds Ratio (95%CI) |
p-value |
PN |
1.03 (0.93, 1.14) |
0.58 |
0.98 (0.92, 1.04) |
0.49 |
0.99 (0.93, 1.06) |
0.82 |
SPN |
0.75 (0.55, 1.03) |
0.08 |
0.97 (0.88, 1.07) |
0.59 |
0.98 (0.89, 1.09) |
0.76 |
Painful neuropathy |
0.84 (0.57, 1.25) |
0.39 |
0.93 (0.83, 1.04) |
0.18 |
0.94 (0.83, 1.06) |
0.31 |
Loss of vibration (Sign) |
0.98 (0.85, 1.13) |
0.78 |
0.95 (0.88, 1.02) |
0.15 |
0.95 (0.88, 1.03) |
0.19 |
Absent reflexes (Sign) |
1.05 (0.93, 1.17) |
0.44 |
0.99 (0.92, 1.07) |
0.83 |
1.00 (0.93, 1.08) |
0.95 |
Loss of vibration and reflexes (Sign) |
0.97 (0.79, 1.19) |
0.80 |
0.96 (0.87, 1.05) |
0.35 |
0.94 (0.85, 1.04) |
0.23 |
Pain (Symptom) |
1.07 (0.90, 1.27) |
0.48 |
0.98 (0.90, 1.06) |
0.62 |
0.99 (0.90, 1.09) |
0.85 |
Symptomatic (Symptom) |
0.96 (0.83, 1.11) |
0.58 |
0.99 (0.93, 1.07) |
0.85 |
1.00 (0.93, 1.08) |
0.99 |
Pins and needles (Symptom) |
0.89 (0.70, 1.12) |
0.31 |
0.98 (0.90, 1.08) |
0.74 |
0.97 (0.88, 1.07) |
0.56 |
Numbness (Symptom) |
0.84 (0.67, 1.05) |
0.13 |
0.91 (0.83, 1.00) |
0.054 |
0.90 (0.81, 1.00) |
0.049 |