Table 2.
Association between neuropathy outcomes and full range pre-ART CD4 counts
| Association between neuropathy outcomes and pre-ART CD4 (per 100 higher cells/µL) | ||||||
| Univariable Logistic Regression GEE Models | ||||||
| At Baseline (pre-ART) | Post-Baseline (post-ART) | Post-Baseline (post-ART), HIV-RNA VL ≤ 50 cp/ml | ||||
| Dependent Variable: | Odds Ratio (95%CI) | p-value | Odds Ratio (95%CI) | p-value | Odds Ratio (95%CI) | p-value |
| PN | 0.99 (0.90, 1.09) | 0.85 | 0.93 (0.89, 0.98) | 0.01 | 0.94 (0.88, 0.99) | 0.01 |
| SPN | 0.69 (0.52, 0.91) | 0.01 | 0.94 (0.86, 1.02) | 0.13 | 0.93 (0.85, 1.02) | 0.13 |
| Painful neuropathy | 0.75 (0.52, 1.08) | 0.12 | 0.95 (0.85, 1.05) | 0.29 | 0.95 (0.85, 1.06) | 0.33 |
| Loss of vibration (Sign) | 0.90 (0.79, 1.04) | 0.15 | 0.92 (0.87, 0.97) | 0.003 | 0.91 (0.85, 0.97) | 0.002 |
| Absent reflexes (Sign) | 1.01 (0.91, 1.12) | 0.85 | 0.94 (0.88, 0.99) | 0.02 | 0.94 (0.88, 1.00) | 0.04 |
| Loss of vibration and reflexes (Sign) | 0.88 (0.72, 1.07) | 0.19 | 0.89 (0.82, 0.97) | 0.003 | 0.86 (0.79, 0.95) | <.001 |
| Pain (Symptom) | 0.94 (0.80, 1.12) | 0.50 | 0.98 (0.91, 1.05) | 0.57 | 0.98 (0.90, 1.06) | 0.62 |
| Symptomatic (Symptom) | 0.88 (0.77, 1.01) | 0.07 | 0.97 (0.91, 1.03) | 0.30 | 0.97 (0.91, 1.03) | 0.31 |
| Pins and needles (Symptom) | 0.83 (0.67, 1.02) | 0.07 | 0.98 (0.91, 1.06) | 0.62 | 0.97 (0.89, 1.05) | 0.39 |
| Numbness (Symptom) | 0.80 (0.65, 0.98) | 0.03 | 0.92 (0.84, 0.99) | 0.03 | 0.91 (0.83, 0.99) | 0.02 |
| Multivariable Logistic Regression GEE Models | ||||||
| At Baseline (pre-ART) | Post-Baseline (post-ART) | Post-Baseline (post-ART), HIV-RNA VL ≤ 50 cp/ml | ||||
| Dependent Variable: | Odds Ratio (95%CI) | p-value | Odds Ratio (95%CI) | p-value | Odds Ratio (95%CI) | p-value |
| PN | 1.03 (0.93, 1.14) | 0.58 | 0.98 (0.92, 1.04) | 0.49 | 0.99 (0.93, 1.06) | 0.82 |
| SPN | 0.75 (0.55, 1.03) | 0.08 | 0.97 (0.88, 1.07) | 0.59 | 0.98 (0.89, 1.09) | 0.76 |
| Painful neuropathy | 0.84 (0.57, 1.25) | 0.39 | 0.93 (0.83, 1.04) | 0.18 | 0.94 (0.83, 1.06) | 0.31 |
| Loss of vibration (Sign) | 0.98 (0.85, 1.13) | 0.78 | 0.95 (0.88, 1.02) | 0.15 | 0.95 (0.88, 1.03) | 0.19 |
| Absent reflexes (Sign) | 1.05 (0.93, 1.17) | 0.44 | 0.99 (0.92, 1.07) | 0.83 | 1.00 (0.93, 1.08) | 0.95 |
| Loss of vibration and reflexes (Sign) | 0.97 (0.79, 1.19) | 0.80 | 0.96 (0.87, 1.05) | 0.35 | 0.94 (0.85, 1.04) | 0.23 |
| Pain (Symptom) | 1.07 (0.90, 1.27) | 0.48 | 0.98 (0.90, 1.06) | 0.62 | 0.99 (0.90, 1.09) | 0.85 |
| Symptomatic (Symptom) | 0.96 (0.83, 1.11) | 0.58 | 0.99 (0.93, 1.07) | 0.85 | 1.00 (0.93, 1.08) | 0.99 |
| Pins and needles (Symptom) | 0.89 (0.70, 1.12) | 0.31 | 0.98 (0.90, 1.08) | 0.74 | 0.97 (0.88, 1.07) | 0.56 |
| Numbness (Symptom) | 0.84 (0.67, 1.05) | 0.13 | 0.91 (0.83, 1.00) | 0.054 | 0.90 (0.81, 1.00) | 0.049 |