Table 2.

Association of obesity and insulin resistance with small vessel disease

		WMH progression (Q5 v. Q1–4)	Incident lacunes 3–20mm
		Odds ratio, 95% Confidence Interval
Insulin*	0.95	0.79, 1.14	1.11	0.91, 1.35
HOMA-IR*	1.00	0.84, 1.19	1.15	0.96, 1.38
Body mass index*	1.01	0.84, 1.21	1.04	0.83, 1.30
Waist circumference*	1.05	0.89, 1.25	1.12	0.91, 1.40
Waist-to-hip ratio*	1.08	0.90, 1.30	1.30	1.03, 1.65
Triglycerides*	0.93	0.76, 1.13	1.24	1.04, 1.47
High density lipoprotein*	1.12	0.93, 1.36	0.77	0.59, 0.99
Systolic blood pressure* ț	1.33	1.12, 1.58	1.20	0.97, 1.48
MetS ț	1.12	0.79, 1.59	1.98	1.28, 3.05
IR score*ț	1.11	0.92, 1.33	1.33	1.05, 1.68

Q= quintile; HOMA-IR = Homeostatic model assessment, insulin resistance;

^*1-standard deviation increase; Adjustments for age, sex, education, race, history of coronary artery disease, history of alcohol use, tobacco use and hypertension;

^țNo adjustments for hypertension