Table 3.

Association of obesity and insulin resistance with incident lacunes, by size

		Incident lacunes3–7mm	Incident lacunes>7–20mm
		Odds ratio, 95% Confidence Interval
Insulin*	1.13	0.89, 1.42	1.16	0.89, 1.51
HOMA-IR*	1.19	0.96, 1.46	1.23	0.97, 1.55
Body mass index*	1.00	0.75, 1.33	1.18	0.87, 1.58
Waist circumference*	1.07	0.82, 1.41	1.34	1.00, 1.81
Waist-to-hip ratio*	1.33	1.00, 1.80	1.43	1.02, 2.00
Triglycerides*	1.32	1.09, 1.60	1.21	0.97, 1.50
High density lipoprotein*	0.73	0.53, 1.02	0.67	0.45, 1.00
Systolic blood pressure* ț	1.22	0.94, 1.60	1.28	0.96, 1.71
MetS ț	1.85	1.09, 3.14	3.34	1.78, 6.30
IR score*ț	1.34	1.01, 1.79	1.62	1.16, 2.25

HOMA-IR = Homeostatic model assessment, insulin resistance;

^*1 standard deviation increase; Adjustments for age, sex, education, race, history of coronary artery disease, history of alcohol use, tobacco use and hypertension;

^țNo adjustments for hypertension