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| activity (nmol product·μmol enzyme–1·min–1) | ||||||
|---|---|---|---|---|---|---|
| TM251 concentration (μM) | wild-type HDAC8 | H180R HDAC8 | G304R HDAC8 | G117E HDAC8 | D233G HDAC8 | P91L HDAC8 |
| 0 | 1140 ± 50 | 0 ± 1 | 0 ± 1 | 67 ± 4 | 470 ± 30 | 950 ± 50 |
| 1 | 1500 ± 40 | 0 ± 1 | 0 ± 1 | 101 ± 6 | 620 ± 40 | 1120 ± 50 |
| 10 | 2030 ± 30 | 0 ± 1 | 0 ± 1 | 150 ± 10 | 850 ± 50 | 1420 ± 60 |
| 100 | 2400 ± 100 | 0 ± 1 | 0 ± 1 | 200 ± 10 | 1070 ± 50 | 1900 ± 100 |
