Skip to main content
. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Oct 7;39(11):2115–2122. doi: 10.1111/acer.12875

Figure 1.

Figure 1

The Notch signaling pathway. Interaction of a ligand (e.g., Delta or Jagged) with the Notch receptor (e.g., N1) initiates cleavage events at site 2 (S2) and site 3 (S3) by α- and γ-secretase, respectively, resulting in release of the intracellular domain of the receptor (NICD) from the cell membrane. NICD is then translocated into the nucleus where it forms a transcription activating complex triggering target gene (Hes, Hrt) transcription. Our data indicate that EtOH inhibits γ-secretase activity and thus, Notch signaling, in vascular SMC.