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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Exp Eye Res. 2015 Aug 25;140:94–105. doi: 10.1016/j.exer.2015.07.022

Fig. 5.

Fig. 5

Treatment with 8-OH-DPAT reduces oxidative stress in the RPE. Sod2flox/floxVMD2-cre mice were treated for one month by daily injection of saline (Control), 0.5 mg/kg of 8-OH-DPAT (Low Dose) or 5.0 mg/kg of 8-OH-DPAT (High Dose). They were then euthanized, enucleated and flat mounts were prepared from their RPE layers. These were stained with Alexa fluor 488 (green) conjugated phalloidin and with antibody to 8-OH-deoxyguanosine. The secondary antibody to detect 8-OH-dG was conjugated to Cy3 (red).