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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Exp Eye Res. 2015 Aug 25;140:94–105. doi: 10.1016/j.exer.2015.07.022

Fig. 6.

Fig. 6

Treatment with 8-OH-DPAT reduces nitrotyrosine levels in the RPE of Sod2-deleted mice. Sod2flox/floxVMD2-cre mice were treated for one month by daily subcutaneous injection of saline (Control), 0.5 mg/kg of 8-OH-DPAT (low dose) or 5.0 mg/kg of 8-OH-DPAT (high dose). Levels of nitrotyrosine modified proteins were measured using a competitive luminescence assay using a nitrated BSA standard curve. Assays were performed in duplicate from the indicated numbers of biological replicates. A. nitrotyrosine levels in RPE samples (n= 4 for high dose and control; n=5). B. nitrotyrosine levels in the retina (n=6 for the control, n=4 for the high dose). (We did not recover low dose retinas for this experiment.) (ns, not significant; *p<0.05). Error bars represent the standard deviation.