Table III.
Desiderable Bias for parameters normally distributed.
| Parameters | Desirable bias | Sample B | Sample C | Sample D | Sample E | Sample F |
|---|---|---|---|---|---|---|
| p vs sample A | p vs sample A | p vs sample A | p vs sample A | p vs sample A | ||
| % bias | % bias | % bias | % bias | % bias | ||
| (95% CLA) | (95% CLA) | (95% CLA) | (95% CLA) | (95% CLA) | ||
| WBC (109/L) | ±5.6% | p=0.0535 | p=0.2108 | p=0.1358 | p=0.0534 | p=0.0844 |
|
| ||||||
| RBC (109/L) | ±1.7% | p=0.1607 | p=0.0031 | p=0.003 | p=0.0025 | p=0.0013 |
| −1.5 | −1.4 | −1 | −3.6 | |||
| (1.6; −4.5) | (0.9; −3.7) | (1.1; −3.1) | (3.1; −10.3) | |||
|
| ||||||
| RDW | ± 1.7% | p=0.003 | p=0,6993 | p<0.0001 | p<0.0001 | p=0,0524 |
| −1.14 | −2.8 | −1.5 | ||||
| (0.73; −3.01) | (0.2; −5.3) | (0.22; −3.29) | ||||
|
| ||||||
| MCHC (g/dL) | ±0.4% | p=0.6916 | p=0.2122 | p=0.1649 | p=0.5391 | p=0.0051 |
| −2.1 | ||||||
| (2.8; −7) | ||||||
|
| ||||||
| MCV (fL) | ±1.2% | p=0.0003 | p<0,0001 | p=0.4929 | p=0.0002 | p<0.0001 |
| 1.05 | −2.2 | 1.6 | 3.4 | |||
| (2.68; −0.58) | (5.1; −0.7) | (4; 0.8) | (6.1;0.7) | |||
|
| ||||||
| PLT-I (109/L) | ±5.9% | p=0.6232 | p=0.0070 | p=0.0057 | p=0.8615 | p=0.0020 |
| 5.3 | 8.6 | 7.8 | ||||
| (17; −6.4) | (22.3; −5.1) | (24.9; −9.4) | ||||
|
| ||||||
| PLT-F (109/L) | ±5.9% | p=0.2557 | p=0.0146 | p=0.0043 | p=0.1931 | p=0.0354 |
| 5.3 | 4 | 2.1 | ||||
| 14.4; −3.8) | (14; −6.1) | (11.7; −7.5) | ||||
|
| ||||||
| MPV (fL) | ±2.3% | p=0.0214 | p=0.8600 | p=0.0748 | p=0.0217 | p=0.1573 |
| −1.7 | −1.7 | |||||
| (3.5; −6.9) | (3.6; −7) | |||||
|
| ||||||
| Parameters |
Desirable bias |
Sample G | Sample H | Sample I | Sample J | |
| p vs sample A | p vs sample A | p vs sample A | p vs sample A | |||
| % bias | % bias | % bias | % bias | |||
| (95% CLA) | (95% CLA) | (95% CLA) | (95% CLA) | |||
|
|
||||||
| WBC (109/L) | ±5.6% | p=0.1957 | p=0.1934 | p=0.1771 | p<0.0001 | |
| 10.1 | ||||||
| (21; −0.7) | ||||||
|
|
||||||
| RBC (109/L) | ±1.7% | p=0.0002 | p=0.6805 | p=0.09 | p=0.5104 | |
| −2.7 | ||||||
| (1.5; −6.9) | ||||||
|
|
||||||
| RDW | ±1.7% | p<0,0001 | p<0.0001 | p=0,0005 | p<0,0001 | |
| −4 | −3.8 | 2.1 | −12.8 | |||
| (−0.4; −7.7) | (1; −8.6) | (5.8; −1.5) | (2.7; −23) | |||
|
|
||||||
| MCHC (g/dL) | ±0.4% | p=0.0347 | p=0.0088 | p=0.0001 | p<0.0001 | |
| 1.8 | 3.1 | −3.8 | 17.5 | |||
| (8; −4.3) | (11; −4.8) | (1.9; −9.4) | (21.9;13) | |||
|
|
||||||
| MCV (fL) | ±1.2% | p=0.0690 | p=0.0004 | p<0.0001 | p<0.0001 | |
| −3.2 | 4 | −17.9 | ||||
| (2.4; −8.8) | (7;1) | (−13.9; −21.9) | ||||
|
|
||||||
| PLT-I (109/L) | ±5.9% | p=0.0036 | p=0.0023 | p=0.0001 | p=0.0014 | |
| 8.4 | 4.8 | 6.9 | 21.9 | |||
| (22.4; −5.6) | (31.5; −22) | (24.1; −10.3) | (58.4; −14.6) | |||
|
|
||||||
| PLT-F (109/L) | ±5.9% | p=0.0037 | p=0.0022 | p=0.0029 | p=0.0012 | |
| 5.8 | 8.7 | 3.7 | 20.7 | |||
| (16.4; −4.9) | (25.1; −7.8) | (15.6; −8.3) | (51.3; −10) | |||
|
|
||||||
| MPV (fL) | ±2.3% | p=0.4375 | p=0.0128 | p=0.0009 | p=0.3022 | |
| −4.5 | −6 | |||||
| (7.3; −16.4) | (4.7; −16.7) | |||||
Mean % bias and 95% confidence limit of agreement (95% CLA) of the samples that had a significant p versus sample A.
CLA: confidence limit of agreement; WBC: white blood cells; RBC: red blood cells; RDW: red blood cell distribution width; MCHC: mean corpuscular haemoglobin concentration; MCV: mean corpuscular volume; PLT-I: platelet count using the impedance technique; PLT-F: platelet count using the fluorescent technique; MPV: mean platelet volume.