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. 2015 Oct 27;48:59. doi: 10.1186/s40659-015-0051-6

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© Chen et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Disruption of CIITA in hESCs by TALENs. a Sequences on exon 2 of human CIITA for target by TALENs.b Alignment of the genomic sequences of mutants and wildtypes (wt) at the TALEN target site. The number of deleted (dashes) or inserted (letters in red) nucleotides compared with the wt sequences is indicated on the left of each sequence. c Efficiency of generation CIITA-deficient hESCs using TALENs in X1