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. 2015 Oct 27;48:59. doi: 10.1186/s40659-015-0051-6

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© Chen et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The pluripotency of CIITA targeted hESCs. a Immunostaining of pluripotent markers, Nanog, Oct4, SSEA3 and Tra-1-60 in CIITA ^−/− hESCs. b HE staining identified three germ layers [mesoderm (left), ectoderm (middle) and endoderm (right)] in teratomas formed from CIITA ^−/− hESCs. Scale bar 100 μm. c RT-PCR analysis of differentiated markers expression in CIITA-targeted hESC-derived EBs. d Karyotype analysis of CIITA heterozygous and homozygous hESCs. Both groups had two samples been analyzed and no abnormal karyotype was found