TABLE 1.

Anti-angiogenic peptides released from collagen in basement membranes

Collagen chain	C-terminal domain	MW	Function	Reference
α1(IV)	Arresten	26 kDa	Inhibits endothelial cell proliferation and migration. Suppresses tumor growth. Stimulates apoptosis.	Colorado et al.[38] Nyberg et al.[39]
α2(IV)	Canstatin	24 kDa	Inhibits endothelial cell proliferation and migration. Suppresses tumor growth. Stimulates apoptosis.	Kamphaus et al.[40] Panka and Mier[41]
α3(IV)	Tumstatin	28 kDa	Inhibits endothelial cell proliferation. Suppresses tumor growth. Stimulates apoptosis.	Maeshima et al [42, 43].
α1(VIII)	Vastatin	18 kDa	Inhibits endothelial cell proliferation. Stimulates apoptosis.	Xu et al [18].
α1(XV)	Restin	22 kDa	Inhibits endothelial cell migration. Suppresses tumor growth.	Ramchandran et al [28]. John et al [29].
α1(XVIII)	Endostatin	20 kDa	Inhibits endothelial cell proliferation and migration. Suppresses tumor growth.	Sasaki et al [32].
α1(XIX)	NC1 domain	2 kDaa	Inhibits endothelial cell migration. Suppresses tumor growth. Inhibits endothelial cell pseudotube formation.	Ramont et al [19].

^aPredicted using 19 amino acid sequence of type XIX collagen’s NC1 domain [19] with ProtParam [44]