Table 3. The effect of studied compounds on body weight, food and water intake.

	Diet-induced obesity control	Yohimbine 2 mg/kg b.w.	Yohimbine 5 mg/kg b.w.	Guanfacine 0.5 mg/kg b.w.	Guanfacine 2 mg/kg b.w.
Total food intake, kcal	2532.2 ± 28.76	2218.2 ± 204.33	1945.3 ± 106.32	2081.2 ± 189.53	1676.9 ± 155.21
Total food intake, g	460.4 ± 5.23	403.3 ± 37.15	353.7 ± 19.33 ##	378.4 ± 34.46	304.9 ± 28.22 ##
Total water intake, ml	831.9 ± 47.50	1041.3 ± 169.70	695.0 ± 40.21 #	904.3 ± 77.78	1288.8 ± 107.10 ##

Food and water intake during 30 days treated using the test compounds in Wistar rats on diet-induced obesity; Treatment: Diet-induced obesity control group—water; Yohimbine at 2 mg/kg b.w., i.p.; Yohimbine at 5 mg/kg b.w., i.p.; Guanfacine at 0.5 mg/kg b.w., i.p.; Guanfacine at 2 mg/kg b.w., i.p.;

^#Significant vs. diet-induced obesity control group, P<0.05;

^##Significant vs. diet-induced obesity control group, P<0.01.