Table 5. Changes in heart rate during 90 minutes after intraperitoneal administration of the studied compounds.
A | time | 0 | 5 | 10 | 15 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | 90 |
mean | 281.5 | 299.8 | 280.2 | 261.8 | 254.2 | 267.5 | 260.5 | 254.7 | 262.0 | 286.5 | 269.2 | 267.2 | |
SEM | 26.49 | 29.22 | 37.20 | 35.95 | 41.40 | 31.92 | 37.21 | 36.91 | 27.53 | 30.62 | 24.6 | 24.27 | |
B | time | 0 | 5 | 10 | 15 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | 90 |
mean | 324.0 | 312.7 | 284.0 | 268.8 | 259.3 | 255.0 | 251.5 | 256.5 | 251.0 | 256.5 | 261.5 | 246.0 | |
SEM | 12.48 | 15.07 | 8.97 | 7.21 | 6.58 | 8.20 | 13.71 | 18.62 | 22.35 | 18.50 | 21.06 | 18.72 | |
* | * | * | * | * | * | * | * | ||||||
C | time | 0 | 5 | 10 | 15 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | 90 |
mean | 275.8 | 270.3 | 259.3 | 247.3 | 238.0 | 226.0 | 215.8 | 209.0 | 201.8 | 194.8 | 194.8 | 191.5 | |
SEM | 23.12 | 7.48 | 6.70 | 6.85 | 6.31 | 6.06 | 6.84 | 6.40 | 7.17 | 6.80 | 6.80 | 6.91 | |
** | *** | *** | *** | *** | *** | *** | |||||||
D | time | 0 | 5 | 10 | 15 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | 90 |
mean | 354.0 | 286.0 | 227.8 | 267.0 | 264.2 | 249.0 | 249.2 | 236.5 | 221.3 | 233.3 | 230.8 | 231.8 | |
SEM | 8.63 | 17.40 | 11.95 | 11.18 | 13.88 | 19.44 | 18.39 | 22.67 | 28.29 | 23.97 | 24.29 | 26.38 | |
* | * | ** | ** | ** | *** | *** | *** | *** | *** | *** |
A Yohimbine 2 mg/kg b.w.; B Yohimbine 5 mg/kg b.w.; C Guanfacine 0.5 mg/kg b.w.; D Guanfacine 2 mg/kg b.w.; Signifcant vs. 0 time
*P<0.05;
**P<0.01;
***P<0.001, ONE-WAY ANOVA