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. 2015 Oct 27;10(10):e0141327. doi: 10.1371/journal.pone.0141327

Table 5. Changes in heart rate during 90 minutes after intraperitoneal administration of the studied compounds.

A time 0 5 10 15 20 30 40 50 60 70 80 90
mean 281.5 299.8 280.2 261.8 254.2 267.5 260.5 254.7 262.0 286.5 269.2 267.2
SEM 26.49 29.22 37.20 35.95 41.40 31.92 37.21 36.91 27.53 30.62 24.6 24.27
B time 0 5 10 15 20 30 40 50 60 70 80 90
mean 324.0 312.7 284.0 268.8 259.3 255.0 251.5 256.5 251.0 256.5 261.5 246.0
SEM 12.48 15.07 8.97 7.21 6.58 8.20 13.71 18.62 22.35 18.50 21.06 18.72
* * * * * * * *
C time 0 5 10 15 20 30 40 50 60 70 80 90
mean 275.8 270.3 259.3 247.3 238.0 226.0 215.8 209.0 201.8 194.8 194.8 191.5
SEM 23.12 7.48 6.70 6.85 6.31 6.06 6.84 6.40 7.17 6.80 6.80 6.91
** *** *** *** *** *** ***
D time 0 5 10 15 20 30 40 50 60 70 80 90
mean 354.0 286.0 227.8 267.0 264.2 249.0 249.2 236.5 221.3 233.3 230.8 231.8
SEM 8.63 17.40 11.95 11.18 13.88 19.44 18.39 22.67 28.29 23.97 24.29 26.38
* * ** ** ** *** *** *** *** *** ***

A Yohimbine 2 mg/kg b.w.; B Yohimbine 5 mg/kg b.w.; C Guanfacine 0.5 mg/kg b.w.; D Guanfacine 2 mg/kg b.w.; Signifcant vs. 0 time

*P<0.05;

**P<0.01;

***P<0.001, ONE-WAY ANOVA