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. 2015 Oct 27;10(10):e0141514. doi: 10.1371/journal.pone.0141514

Fig 3. Experimental data derived from Sanger sequencing of SLC27A4 complementary DNA.

Fig 3

(A) Gene model of ichthyosis-affected in comparison to unaffected Great Danes. In the region of the non-synonymous SNV SLC27A4:g.8684G>A affected dogs show aberrantly spliced transcript with an in-frame loss of the first 54 bp of exon 8. (B) A new acceptor site is created by the A-allele of SLC27A4:g.8684G>A that results in a shorter RNA product. Affected dogs show only a small amount of RNA of the wild type size.