Table 3.
Persistence of weight loss in SEISMIC and the LTE
| SEISMIC | LTE | ||||
|---|---|---|---|---|---|
| Variable | Baseline (n = 29) | Week 24 (n = 29) | Month 6 (n = 27) | Month 18 (n = 25) | Final visit (n = 29) |
| Weight, kg | |||||
| Mean ± SD | 105.4 ± 34.3 | 97.2 ± 30.8 | 95.2 ± 32.2 | 96.6 ± 34.7 | 95.1 ± 32.9 |
| Change weight | — | −8.2 ± 9.3 | −10.5 ± 12.3 | −11.4 ± 18.7 | −10.3 ± 16.3 |
| % Change in weight | — | −7.5 ± 7.1 | −9.7 ± 9.7 | −10.0 ± 14.4 | −9.3 ± 13.4 |
| BMI, kg/m2 | |||||
| Mean ± SD | 37.7 ± 11.7 | 34.7 ± 10.0 | 34.3 ± 9.7 | 34.0 ± 9.7 | 33.7 ± 9.9 |
| BMI category, n (%) | |||||
| ≥ 30 | 21 (72.4) | 17 (58.6) | 16 (59.3) | 16 (64.0) | 18 (62.1) |
| ≥ 40 | 9 (31.0) | 7 (24.1) | 6 (22.2) | 4 (16.0) | 6 (20.7) |
Final visit is defined as the last post-entry observation collected during the LTE study
BMI body mass index; LTE long-term extension