Table 2. Univariate and multivariate analyses of OS in 195 cases of oral cancer.

	Univariate analysis				Multivariate analysis
	HR	95% CI		P value	HR	95% CI		P value
Variable		Low	High			Low	High
Age (> 50 vs. ≦ 50 years)	1.216	0.781	1.892	0.387
Sex (Male vs. Female)	2.295	0.565	9.325	0.246
Stage (III/IV vs. I/II)	3.013	1.953	4.646	< 0.001*	2.019	1.156	3.525	0.013*
Grade (G3 vs. G1/G2)	1.328	0.737	2.393	0.344
Lymphovascular invasion (Present vs. Absent)	3.399	2.211	5.225	< 0.001*	2.406	1.416	4.088	0.001*
Necrosis (Extensive vs. Limited/no)	1.828	1.182	2.825	0.007*	1.272	0.798	2.028	0.313
Cytoplasmic Beclin 1 (High vs. Low)	1.443	0.953	2.186	0.083
Nuclear Beclin 1 (Positive vs. Negative)	1.278	0.734	2.228	0.386
Cytoplasmic Beclin 2
Low vs. Moderate	2.253	1.369	3.709	0.001*	2.698	1.614	4.509	< 0.001*
High vs. Moderate	1.975	1.152	3.388	0.013*	1.865	1.084	3.207	0.024*
Nuclear Beclin 2 (Positive vs. Negative)	1.130	0.639	2.001	0.674

OS, overall survival; CI, confidence interval.

* P< 0.05