Table 3. Univariate and multivariate analyses of DSS in 195 cases of oral cancer.
| Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| Variable | Low | High | Low | High | ||||
| Age (> 50 vs. ≦ 50 years) | 1.097 | 0.647 | 1.861 | 0.731 | ||||
| Sex (Male vs. Female) | 3.090 | 0.428 | 22.308 | 0.263 | ||||
| Stage (III/IV vs. I/II) | 5.608 | 3.082 | 10.205 | < 0.001* | 4.161 | 2.086 | 8.299 | < 0.001* |
| Grade (G3 vs. G1/G2) | 1.367 | 0.673 | 2.777 | 0.387 | ||||
| Lymphovascular invasion (Present vs. Absent) | 3.399 | 2.211 | 5.225 | < 0.001* | 2.599 | 1.430 | 4.726 | 0.002* |
| Necrosis (Extensive vs. Limited/no) | 1.692 | 0.990 | 2.891 | 0.054 | ||||
| Cytoplasmic Beclin-1 (High vs. Low) | 1.955 | 1.180 | 3.238 | 0.009* | 1.706 | 1.021 | 2.850 | 0.041* |
| Nuclear Beclin-1 (Positive vs. Negative) | 1.751 | 0.947 | 3.239 | 0.074 | ||||
| Cytoplasmic Beclin-2 | ||||||||
| Low vs. Moderate | 3.024 | 1.635 | 5.590 | < 0.001* | 3.984 | 2.115 | 7.502 | < 0.001* |
| High vs. Moderate | 2.065 | 1.031 | 4.134 | 0.041* | 1.722 | 0.853 | 3.480 | 0.130 |
| Nuclear Beclin-2 (Positive vs. Negative) | 1.363 | 0.708 | 2.621 | 0.354 | ||||
DSS, disease specific survival; CI, confidence interval.
* P< 0.05