Table II.
Distribution of genotypes and alleles of the c.972G>C polymorphism of the MUTYH gene and odds ratio (OR) with 95% confidence interval (95% CI) in patients with KC and controls
| Genotype/allele | Controls (n = 220) | KC (n = 205) | Crude OR (95% CI) | Value of p | Adjusted ORa (95% CI) | Value of p | ||
|---|---|---|---|---|---|---|---|---|
| Number | Frequency | Number | Frequency | |||||
| G/G | 142 | 0.65 | 136 | 0.66 | 1.08 (0.73–1.62) | 0.697 | 1.28 (0.82–2.01) | 0.286 |
| G/C | 73 | 0.33 | 62 | 0.30 | 0.87 (0.58–1.32) | 0.516 | 0.73 (0.46–1.16) | 0.184 |
| C/C | 5 | 0.02 | 7 | 0.04 | 1.52 (0.48–4.87) | 0.481 | 1.72 (0.41–7.26) | 0.464 |
| χ2 = 0.83; p = 0.6601 | ||||||||
| G | 357 | 0.81 | 334 | 0.81 | 1.02 (0.72–1.46) | 0.901 | 1.17 (0.78–1.74) | 0.456 |
| C | 83 | 0.19 | 76 | 0.19 | 0.98 (0.69–1.39) | 0.901 | 0.86 (0.57–1.28) | 0.456 |
a
OR adjusted for co-occurrence of visual impairment, allergies, sex and family history for KC.