Table III.
Distribution of genotypes and alleles of the c.977C>G polymorphism of the hOGG1 gene and odds ratio (OR) with 95% confidence interval (95% CI) in patients with KC and controls
| Genotype/allele | Controls (n = 220) | KC (n = 205) | Crude OR (95% CI) | Value of p | Adjusted ORa (95% CI) | Value of p | ||
|---|---|---|---|---|---|---|---|---|
| Number | Frequency | Number | Frequency | |||||
| C/C | 144 | 0.65 | 125 | 0.61 | 0.83 (0.55–1.22) | 0.415 | 0.83 (0.54–1.29) | 0.415 |
| C/G | 69 | 0.31 | 70 | 0.34 | 1.14 (0.76–1.70) | 0.541 | 1.18 (0.75–1.85) | 0.483 |
| G/G | 7 | 0.03 | 10 | 0.05 | 1.56 (0.58–4.18) | 0.376 | 1.96 (0.41–3.53) | 0.746 |
| χ2 = 1.35; p = 0.5089 | ||||||||
| C | 357 | 0.81 | 320 | 0.78 | 0.83 (0.59–1.16) | 0.263 | 0.86 (0.59–1.25) | 0.422 |
| G | 83 | 0.19 | 90 | 0.22 | 1.21 (0.87–1.70) | 0.263 | 1.17 (0.80–1.70) | 0.422 |
a
OR adjusted for co-occurrence of visual impairment, allergies, sex and family history for KC.