Table IV.
Distribution of combined genotypes of the c.977C>G polymorphism of hOGG1 and c.972G>C polymorphism of MUTYH and odds ratio (OR) with 95% confidence interval (95% CI) in patients with KC and controls
| Genotype/allele | Controls (n = 220) | KC (n = 205) | Crude OR (95% CI) | Value of p | Adjusted ORa (95% CI) | Value of p | ||
|---|---|---|---|---|---|---|---|---|
| Number | Frequency | Number | Frequency | |||||
| G/G–C/C | 91 | 0.41 | 80 | 0.39 | 0.91 (0.62–1.34) | 0.623 | 0.99 (0.64–1.52) | 0.952 |
| G/G–C/G | 46 | 0.21 | 51 | 0.25 | 1.25 (0.80–1.97) | 0.330 | 1.45 (0.87–2.41) | 0.156 |
| G/G–G/G | 5 | 0.02 | 5 | 0.02 | 1.08 (0.31–3.77) | 0.910 | 0.75 (0.19–3.05) | 0.688 |
| G/C–C/C | 48 | 0.22 | 43 | 0.21 | 0.95 (0.60–1.51) | 0.832 | 0.81 (0.49–1.35) | 0.423 |
| G/C–C/G | 23 | 0.10 | 14 | 0.07 | 0.63 (0.31–1.26) | 0.188 | 0.55 (0.25–1.22) | 0.141 |
| G/C–G/G | 2 | 0.01 | 5 | 0.02 | 2.73 (0.52–14.20) | 0.234 | 2.27 (0.40–12.94) | 0.355 |
| C/C–C/C | 5 | 0.02 | 2 | 0.01 | 0.42 (0.08–2.21) | 0.308 | 0.76 (0.11–5.41) | 0.789 |
| C/C–C/G | 0 | – | 5 | 0.02 | – | – | – | – |
| C/C–G/G | 0 | – | 0 | – | – | – | – | – |
a
OR adjusted for co-occurrence of visual impairment, allergies, sex and family history for KC.