Table 4. Global and regional estimates of the prevalence of, and total number of individuals with, genital herpes infection due to either HSV-1 or HSV-2 among 15–49 year olds in 2012, by sex, as a function of the assumed proportion of incident HSV-1 infections in this age group that are genital.

ASSUMING 50% OF INCIDENT HSV-1 INFECTIONS AMONG 15–49 YEAR OLDS ARE GENITAL
Females			Males
Region	Prevalence of genital HSV infection (%)	Number with HSV-1 or HSV-2 genital infection (millions)	Region	Prevalence of genital HSV infection (%)	Number with HSV-1 or HSV-2 genital infection (millions)
Americas	26	65	Americas	20	48
Africa	38	81	Africa	25	54
Eastern Mediterranean	14	22	Eastern Mediterranean	5	9
Europe	14	32	Europe	14	31
South-East Asia	9	42	South-East Asia	7	34
Western Pacific	16	80	Western Pacific	9	47
Global total (females)	18	322	Global total (males)	12	223
Global total (all)	544 million (15%)
ASSUMING 85% OF INCIDENT HSV-1 INFECTIONS AMONG 15–49 YEAR OLDS ARE GENITAL
Females			Males
Region	Prevalence of genital HSV infection (%)	Number with HSV-1 or HSV-2 genital infection (millions)	Region	Prevalence of genital HSV infection (%)	Number with HSV-1 or HSV-2 genital infection (millions)
Americas	32	78	Americas	26	63
Africa	38	81	Africa	25	54
Eastern Mediterranean	15.5	24	Eastern Mediterranean	6.5	11
Europe	18	39	Europe	21	47
South-East Asia	9	42	South-East Asia	7	35
Western Pacific	19	95	Western Pacific	12	64
Global total (females)	20	360	Global total (males)	15	273
Global total (all)	633 million (17%)

Totals may be slightly different due to rounding. Prevalence (and corresponding numbers infected) reduced by estimated fraction of infections that are co-infections (genital HSV-1 prevalence * HSV-2 prevalence) to avoid double counting, assuming that genital HSV-1 does not occu after HSV-2 infection, and that HSV-2 infection is independent of previous infection with genital HSV-1. Note that this table is for infection, not disease.