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. 2015 Oct 28;10(10):e0141773. doi: 10.1371/journal.pone.0141773

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© 2015 Çelen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — (A) Workflow for identifying beta-catenin transcriptional targets that affect beta-catenin transcriptional activity, thereby participating in positive and/or negative feedback loops. (B) Sub-network of beta-catenin interacting proteins whose expression is regulated by a transcription factor co-activated by beta-catenin (“target-interactors”). Node fill color indicates the effect of the interacting proteins on beta-catenin transcriptional activity. Nodes with heavy borders represent genes for which there is experimental evidence of transcriptional regulation by beta-catenin.