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. 2015 Oct 28;10(10):e0141773. doi: 10.1371/journal.pone.0141773

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© 2015 Çelen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — (A) Workflow for exploring effects of CDK5 on beta-catenin transcriptional activity. (B) Sub-network of CDK5 substrates (blue nodes) in the beta-catenin network (Step 1 of workflow) (C) Sub-network of CDK5 substrates selected for further study (Step 2 of workflow). Pathways through which CDK5 kinase activity affects beta-catenin (CTNNB1) phosphorylation state and transcriptional activity are shown.