Table 3.
Clinical characteristics of patients operated by abdominoperineal excision in Sweden 2007–2009
| Total cohort, n = 1319 | |||||
|---|---|---|---|---|---|
| Included in the analysis | Deceased at follow-up | Non-responders | p value | ||
| Number of patients | 545 | 467 | 307 | ||
| Sex | Female | 218 (40.0 %) | 170 (36.4 %) | 142 (46.3 %) | 0.076 |
| Male | 327 (60.0 %) | 297 (63.6 %) | 165 (53.7 %) | ||
| Age at operation | 66.0 | 71.9 | 69.3 | <0.001 | |
| BMI | 29.3 | 27.3 | 26.8 | 0.944 | |
| ASA classification | ASA 1 | 144 (27.0 %) | 69 (15.3 %) | 61 (20.5 %) | <0.001 |
| ASA 2 | 314 (58.9 %) | 235 52.2 %) | 165 (55.4 %) | ||
| ASA 3 | 73 (13.7 %) | 137 (30.4 %) | 72 (24.2 %) | ||
| ASA 4 | 2 (0.4 %) | 9 (2.0 %) | 0 | ||
| Radiation therapy | None | 64 (11.8 %) | 123 (26.7 %) | 64 (20.9 %) | <0.01 |
| Short (5 × 5 Gy) | 355 (65.6 %) | 222 (48.2 %) | 181 (59.2 %) | ||
| Long (25 × 1,8/2 Gy) | 122 (22.6 %) | 116 (25.2 %) | 61 (19.9 %) | ||
| Chemoradiotherapy | Yes | 110 (20.2 %) | 112 (24.0 %) | 57 (18.6 %) | 0.560 |
| No | 434 (79.8 %) | 354 (76 %) | 250 (81.4 %) | ||
| Tumor heighta | 4,1 | 4,3 | 4,3 | 0.811 | |
| pT stage | T0–T2 | 256 (47.9 %) | 98 (21.2 %) | 130 (42.9 %) | 0.385 |
| T3 | 252 (47.1 %) | 289 (62.4 %) | 156 (51.5 %) | ||
| T4 | 27 (5.0 %) | 76 (16.4 %) | 17 (5.6 %) | ||
| pN stage | N0 | 344 (63.9 %) | 187 (41.1 %) | 202 (68.2 %) | 0.354 |
| N1 | 130 (24.2 %) | 117 (25.7 %) | 67 (22.6 %) | ||
| N2 | 64 (11.9 %) | 151 (33.2 %) | 27 (9.1 %) | ||
| Microscopic radicalityb | Yes | 522 (96.0 %) | 386 (83.0 %) | 285 (92.8 %) | <0.05 |
| No/indeterminate | 22 (4.0 %) | 79 (17.0 %) | 22 (7.2 %) | ||
| Perineal dissection | Conventional APE | 71 (13.0 %) | 79 (16.9 %) | 59 (19.2 %) | <0.05 |
| ELAPE | 222 (40.7 %) | 172 (36.8 %) | 124 (40.45) | ||
| Indeterminate | 252 (46.2 %) | 216 (46.3 %) | 124 (40.4 %) | ||
| Coccyx resection | Yes | 124 (27.7 %) | 133 (35.6 %) | 73 (28.4 %) | 0.850 |
| No | 323 (72.3 %) | 241 (64.4 %) | 184 (71.6 %) | ||
| Perineal reconstruction | Suture | 430 (79.6 %) | 352 (76.4 %) | 238 (78.3 %) | 0.803 |
| Mesh | 64 (11.9 %) | 56 (12.1 %) | 36 (11.8 %) | ||
| Flap | 46 (8.5 %) | 53 (11.5 %) | 30 (9.9 %) | ||
p values refer to differences between included patients and non-responders
BMI body mass index, ASA American Society of Anesthesiologists, APE abdominoperineal excision, ELAPE extralevator abdominoperineal excision
aDistance in centimeter from the lower edge of the tumor to the anal verge
bCircumferential resection margin >1 mm