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Schematic structures of ranibizumab (A), bevacizumab (B), and aflibercept (C). Ab stands for antibody, Fab stands for fragment antigen binding, Fc stands for fragment crystallizable region. R1d2 stands for domain 2 of vascular endothelial growth factor receptor VEGFR1 and R2d3 stands for domain 3 of VEGFR2. Black bars correspond to inter-chain disulfide bridges.
