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. 2015 Oct 29;6:248. doi: 10.3389/fphar.2015.00248

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Copyright © 2015 Platania, Di Paola, Leggio, Romano, Drago, Salomone and Bucolo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Residue based-root mean square fluctuations (RMSF) of complexes. RMSF increases from blue to red color. Bound VEGFA molecule is highlighted with a red circle. (A) VEGFR1d2_R2d3/VEGFA. (B,C) Fab-bevacizumab/VEGFA, respectively from top and side view. (D,E) Ranibizumab/VEGFA respectively, from top and side view.