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High frequency H-bonds at anti-VEGF/VEGFA interfaces.
| Anti-VEGF/VEGFA | |
|---|---|
| Ranibizumab | Tyr102/Glu93; Tyr101/Glu93; Tyr101/Glu79; Ser106/His90; Tyr99/Glu87; Tyr96/Glu87; Tyr34/Glu89; Thr53/Glu89; Tyr54/Tyr21; Trp50/His89. |
| Fab-bevacizumab | His101/Glu93; Tyr102/Glu93; Ser106/His90; Thr53/Gln89; Tyr54/Tyr21. |
| VEGFR1d2_R2d3 | Arg96/Asp93; Gln97/Lys107; Glu73/Arg105; Glu73/Arg103. |
In the couple X/Y, X, and Y are respectively the residues of anti-angiogenic agent and VEGFA, involved in the H-bond.
