Table 3.
Receiver-operating characteristic analysis of methylated genes for diagnosis of GC.
| Gene | Number of controls/CAG samples without DNA methylation detected/total number of controls/CAG samples (%) | Number of GC samples with DNA methylation detected/total number of GC samples (%) | Specificity | Sensitivity | AUC (SE) | 95% CI |
|---|---|---|---|---|---|---|
| FLNC | 80/86 (93.0) | 55/82 (67.1) | 93.0 | 67.1 | 0.718 (0.037) | 0.65–0.79 |
| THBS1 | 81/86 (94.2) | 52/82 (63.4) | 94.2 | 63.4 | 0.706 (0.038) | 0.63–0.78 |
| UCHL1 | 77/86 (89.5) | 46/82 (56.1) | 89.5 | 56.1 | 0.663 (0.041) | 0.60–0.73 |
| DLEC1 | 80/86 (93.0) | 66/82 (80.5) | 93.0 | 80.5 | 0.868 (0.033) | 0.80–0.91 |
GC, gastric cancer; CAG, chronic atrophic gastritis; AUC, area under the curve; SE, standard error; CI, confidence internal.