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. Author manuscript; available in PMC: 2016 Jan 29.
Published in final edited form as: Cell. 2015 Jan 22;160(3):477–488. doi: 10.1016/j.cell.2014.12.016

Figure 1. MYC Expression, Longevity, Body Mass and Composition.

Figure 1

(A) MYC mRNA and protein expression. mRNA was measured by qRT-PCR. Protein was measured by immunoblotting of tail fibroblasts or by IF of liver sections. Fibroblasts: N=3, 3 months, females. Liver: N=3–5, 5–9 months, both sexes.

(B) Survival of Myc+/+ (blue) and Myc+/− (red) mice. Each data point shows one animal (N, number of animals in each cohort).

(C) Lifelong trends of whole body weights. Median weights (3-week sliding window) of the aging cohorts in (B). Inset: weights at 500 days and relative weights of Myc+/− animals.

(D) Relative adiposity. Animals were scanned by micro-CT imaging. Left: volume of all white fat as percent of total volume of the animal. Right: volume of visceral fat as percent of total fat. N=6, 5 months.

See also Figure S1 and Tables S1 and S2.