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. Author manuscript; available in PMC: 2016 Jan 29.
Published in final edited form as: Cell. 2015 Jan 22;160(3):477–488. doi: 10.1016/j.cell.2014.12.016

Figure 2. Metabolic Hormones, Fecundity and Cancer Incidence.

Figure 2

(A–C) Levels of adiponectin, leptin, and free IGF-1 in plasma. Blood samples were collected after overnight fasting. N=5–12, 5 and 22 months, females.

(D) Lifetime reproductive output. Myc+/− and Myc+/+ females (N=5) were bred with Myc+/+ males (left), and Myc+/− and Myc+/+ males (N=7–9) were bred with Myc+/+ females (right).

(E) Sexual maturation of females. N=12–19.

(F) Left: Cause of death determined by a veterinary pathologist. N=19 Myc+/+, 38 Myc+/−, both sexes. Right: Incidence of macroscopic cancer noted at time of autopsy (Myc+/+, 73.4%; Myc+/−, 53.7%; p=0.03). N=64 Myc+/+, 67 Myc+/−, both sexes.

(G) Histopathological analysis was used to determine the spread (left; number of affected tissues) and severity (right; maximum grade) of lymphoma. N=12 Myc+/+, 27 Myc+/−, both sexes.

See also Figure S2 and Table S3.