Table 1. Linkage analysis of AJ and C57BL/6J phenotypic differences using the recombinant inbred AXB/BXA mice.
| Stimulation | Phenotype | QTL position (Chr) | QTL peak position (Mb) | LOD | Adjusted p value | Gene location |
|---|---|---|---|---|---|---|
| LPS | CCL22 | 8 | 109.50 | 6.6 | 0.001 | Ccl22, 8 (94.94–94.75) |
| LPS | IL-12 | 11 | 37.48 | 5.5 | 0.006 | IL12p40, 11 (44.40–44.41) |
| IFNG+TNF | Nitric Oxide | 12 | 9.21 | 2.9 | 0.06 * | Nos2, 11 (78.92–78.96) |
| IL-4 | Arginase activity | 10 | 21.12 | 3.8 | 0.08 * | Arg1, 10 (24.91–24.92) |
| LPS | IL-10 | 1 | 76.52 | 3.3 | 0.06 * | Il10, 1(131.0–131.0) |
| IFNG+TNF | Parasite growth | 3 | 147.75 | 4.1 | 0.08 * | - |
| LPS | Arginase activity | 1 | 22.1 | 2.1 | 0.77 | Arg1, 10 (24.91–24.92) |
| CPG | IL-10 | 1 | 40.6 | 2.9 | 0.16 | Il10, 1(131.0–131.0) |
| CPG | CCL22 | X | 99.93 | 0.20 | Ccl22, 8 (94.94–94.75) | |
| Control | Parasite growth | 3 | 147.75 | 2.7 | 0.33 | - |
| IFNG+TNF+AG | Parasite growth | 3 | 147.75 | 3.4 | 0.10 | - |
| IFNG+TNF+AG | NO | 15 | 87.67 | 2.5 | 0.46 | Nos2, 11 (78.92–78.96) |
QTL were deemed significant at an adjusted p< 0.01 calculated after 1000 permutations in R/qtl. Shown are the individual phenotypes and the corresponding adjusted p-values for each LOD score.
* = Suggestive QTL. Gene location indicates the physical location, chromosome followed by position (Mb) in parenthesis, of the gene coding for the measured phenotype.