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. 2015 Oct 28;11(10):e1005619. doi: 10.1371/journal.pgen.1005619

Table 2. QTL inheritance and allele effects on different traits in AXB/BXA BMDM.

Chr Stimulation Trait Marker AA (Mean) BB (Mean) P-value
6 LPS CCL22 rs3695724 409.2 786.8 1.8e-3
8 LPS CCL22 rs6182338 874.8 334.0 8.8e-8
18 LPS CCL22 rs3720827 806.7 450.5 3.5e-3
11 LPS IL-12 rs13480972 56.7 199.8 1.1e-6
16 LPS IL-12 rs4188825 172 69.1 2.3e-3
17 LPS IL-12 rs3684732 48.7 145.2 1.9e-3
4 IFN+TNF Nitric Oxide rs3723703 9.9 15.1 1.3e-3
12 IFN+TNF Nitric Oxide rs6176675 14.7 9.2 4.6e-4
1 IL-4 Arginase activity mCV23695025 2.5 2.1 9.4e-4
10 IL-4 Arginase activity CEL-10_2111704 1.5 1.2 1.1e-1
1 LPS IL-10 mCV24115911 204.8 89.9 3.0e-4
4 LPS IL-10 gnf04.019.134 114.4 180.3 4.2e-1
2 IFN+TNF Parasite growth D2Mit5 2.4 x 105 2.7 x 105 1.9e-1
3 IFN+TNF Parasite growth gnf03.151.552 2.2 x 105 3.1 x 105 2.8e-5
1 LPS Arginase activity mCV23695025 2.0 1.6 3.2e-3
5 LPS Arginase activity rs13478413 1.8 2.1 1.4e-2
3 Control Parasite growth gnf03.151.552 8.9 x 105 1.2 x 106 1.4e-3
13 Control Parasite growth rs13481799 1.0 x 106 8.1 x 105 7.1e-3
3 IFN+TNF+AG Parasite growth gnf03.151.552 1.9 x 105 3.0 x 105 6.1e-3
X IFN+TNF+AG Parasite growth CEL-X_66015326 2.7 x 105 2.0 x 105 8.2e-3
1 CPG IL-10 rs3677272 3.0 x 103 2.0 x 103 1.2e-3
10 CPG IL-10 rs6197175 3.3 x 103 2.2 x 103 1.0e-3
X CPG CCL22 CEL-X_94143306 253.6 96.3 4.7e-3
2 CPG CCL22 rs3726974 270.6 106.2 5.3e-3

AA = Homozygous AJ allele; BB = Homozygous B6 allele. BMDMs were grouped based on their genotypes at the marker on the QTL peak. P-values were corrected for multiple testing (26 individuals) using the Bonferroni test.