Table 3. Functional enrichments in the large trans-eQTL hotspots in AXB/BXA macrophages following IFNG+TNF-stimulation, CpG-stimulation, or Toxoplasma-infection.
| Stimulation | Trans-band | Functional enrichment | Adjusted P-value | Enriched TF | P-value |
|---|---|---|---|---|---|
| IFNG+TNF | 12 (4.4–13.1) | Purine metabolism | 5.72e-05 | E2f6 | 0.0008 |
| Nitrogen compound metabolic process | 2.95e-05 | Creb | 0.0001 | ||
| CpG | X (139.6–141.1) | Histone H3-K4 acetylation | 1.80e-03 | Sp1 | 4.92e-05 |
| Positive regulation of nucleic acid-templated transcription | 7.91e-03 | ||||
| Toxoplasma | 2 (161.5–168.3) | Negative regulation of histone H3-K27 methylation | 2.04e-02 | Sp1 | 1.05e-18 |
| Positive regulation of purine nucleotide catabolic process | 5.11e-02 | Egr1 | |||
| Zfp148 | 4.16e-15 | ||||
| 1.40e-15 | |||||
| 10 (117.1–127.8) | Leukocyte differentiation | 2.31e-04 | Zscan10 | 6.20e-08 | |
| Positive regulation of protein deacetylation | 2.97e-03 | Hif1 | |||
| Xbp1 | 1.94e-05 | ||||
| 5.37e-04 | |||||
| 13 (47.0–57.7) | Fc-gamma receptor signaling | 2.10e-04 | Elk3 | 5.53e-09 | |
| Natural Killer cell mediated immunity | 1.83e-03 | Etv5 | |||
| Ets2 | 1.80e-05 | ||||
| 5.15e-04 |