Figure 6.

Alterations in Effective Connectivity in SFC-Derived Neuronal Networks

Structure of representative WT and control (GFP-transduced) or gene complemented (HGSNAT-transduced) SFC7-iPSC-derived neuronal networks at 3 (top) and 9 (bottom) weeks of differentiation, as reconstructed through GTE methods. In all the depicted networks, circles show the actual position of the neurons in the culture and are color-coded according to their relative connectivity. For easier visualization, the number of neurons in each network is limited to 150, which are randomly chosen from the original set, and only those connections with p values < 0.002 are represented.