Fig 5. Demethylation of HPV16 LCR CpG sites induces apoptosis and cell cycle arrest.

A) After demethylation of the CpG sites, the number of apoptotic cells increased significantly in UM-SCC47 and CaSki cells, but not in SiHa cells. B) After demethylation of the CpG sites, the number of cells arrested during both S and G2/M phases increased in UM-SCC47 and CaSki cells, but not in SiHa cells. All data are means ± SEM from 3 independent experiments.