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. 2015 Oct 29;6:552. doi: 10.3389/fimmu.2015.00552

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Copyright © 2015 Rao, Hoof, van Baarle, Keşmir and Textor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NS5B is enriched in experimentally verified epitopes restricted by protective HLA allele groups (HLA-B*27, HLA-B*57). (A) The distribution of (non-redundant) experimentally verified epitopes restricted by the protective alleles. (B) The distribution of all non-redundant HCV epitopes reported in the IEDB and LANL databases. (C) The normalized length of each protein in the complete HCV proteome. The abundance of NS5B in (A) significantly differs from what would be expected based on the distributions in (B) (p = 0.0006) and (C) (p = 0.006; Fisher’s exact test).