Table 3.

Predicted HLA-B*27 epitopes that have both low entropy and high binding affinity.

Epitope	Protein	Positiona	Entropy (bits)b	Predicted IC50 (nM)
RRGPRLGVR	CORE	39–47	0.03	132
SRCGSGPWI	E2	212–220	0.037	1003
YRLWHYPCT	E2	230–238	0.037	586
RRGRTGRGK	NS3	461–469	0.036	234
NRLIAFASR	NS4B	206–214	0.018	865
ERLYVGGPL	NS5B	258–266	0	786
YRRCRASGV	NS5B	276–284	0.024	491
RRCRASGVL	NS5B	277–285	0.024	115
ARAAWETAR	NS5B	393–401	0.024	156
QRLHGLSAF	NS5B	464–472	0.024	496
LRKLGVPPL	NS5B	489–497	0	438
RKLGVPPLR	NS5B	490–498	0	824
LRAWRHRAR	NS5B	497–505	0.024	251
WRHRARSVR	NS5B	500–508	0.024	238
HRARSVRAR	NS5B	502–510	0.024	264
ARSVRARLL	NS5B	504–512	0.024	170

^aPosition with respect to the HCV reference strain H77.

^bThe median entropy in the nine-mer.