Figure 4. CoPP treatment suppresses BVDV of post-infection viral replication.

MDBK cells infected with BVDV at a MOI of 1 were treated with 80 μM CoPP at the indicated times from 2 hpi, and then intracellular HO-1, BVDV RNA (A) and protein (B), and virus titers (C) in the supernatants were analyzed by qRT-PCR, Western blot, and CCID₅₀. Data are expressed as mean ± s.d. of three independent experiments, *P < 0.05, **P < 0.01, and ***P < 0.001.