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. 2015 Oct 29;5:15676. doi: 10.1038/srep15676

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Copyright © 2015, Macmillan Publishers Limited

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(A–C) Dual immunostaining for Sall1 (red) and Six2 (green) in Sall1^flox/flox and Foxd1Cre; Sall1^flox/flox kidneys at E12.5. Sall1 expression in the stroma (arrowheads) is absent but is retained in the nephron progenitors (arrows) that are positive for Six2. ub: ureteric bud. (D) Immunostaining for Sall1 (red) and Aldh1a2 (green) of Sall1^flox/flox and Foxd1GFPCre; Sall1^flox/flox kidneys at E12.5. Note the absence of Sall1 in the Aldh1a2-positive stromal cells (arrows). (E,F) Dual immunostaining for Six2 (red) and Aldh1a2 (green) at E14.5. Six2-positive nephron progenitors (arrows) are expanded, while Aldh1a2-positive stromal cells (arrowheads) are retained in the mutant kidney. Some stromal cells (asterisks) reach the ureteric bud (ub) tip epithelium in the control. (G) Dual immunostaining for Six2 (green) and Ncam (red) at E14.5. Nephron progenitors are expanded, but the Ncam-positive nascent nephrons (yellow arrowheads) are formed. Scale bars = 20 μm.