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. 2015 Oct 29;5:15806. doi: 10.1038/srep15806

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(a) Superposition of ¹H-¹³C HSQC spectra showing the M230 peak of the p66 subunit in HIV-1 RT with nevirapine (red), efavirenz (purple) and rilpivirine (green), delavirdine (blue), dapivirine (orange), and etravirine (magenta). (b) Correlation between anti-HIV-1 RT activity reported by Yang et al.²² and the ¹³C chemical shift of M230 of the HIV-1 RT p66 subunit upon binding to these inhibitors. Linear regression analyses showed a significant correlation between the chemical shift and pEC₅₀ values (r² = 0.91, p = 0.012, *p < 0.05).