Figure 1. Tau is rapidly dephosphorylated site-specifically in mouse brains during postmortem.

Mice were scarified by cervical dislocation. The dead animal bodies were kept at room temperature for the indicated periods of time. (A) Phosphorylation of tau was analyzed by Western blots developed with phosphorylation-dependent and site-specific tau antibodies indicated at the right side of the blots. (B) The levels of tau phosphorylation at individual sites were quantified and normalized with total tau level and presented as mean ± SEM. (n = 3–4). *p < 0.05; **p < 0.01.