Figure 8. PGBD5 homologs are divergent from other piggyBac genes in vertebrates.
Phylogenetic reconstruction of the evolutionary relationships among piggyBac transposase-derived genes in vertebrates, demonstrating the PGBD5 homologs represent a distinct subfamily of piggyBac-like derived genes. Scale bar represents Grishin distance.
Figure 8—figure supplement 1. PGBD5 glutamic acid resitues D168, D194, and D386 are conserved across species.
Clustal O alignment of PGBD5 proteins across species (Danio rerio, Xenopus tropicalis, Homo sapiens, Mus musculus, Gallus gallus, Python bivittatus). D168, D194, and D386 residues are highlighted in yellow.