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Illustrative case of spinal cord pathology evident for a subject with PPMS (age 58, EDSS 6.5) compared to a control (age 58). The same colour scale was used for both participants. While 2 lesions were noted within the PPMS cervical spinal cord by a neuroradiologist (NS), markedly lower mcDESPOT VFM values are apparent throughout the PPMS spinal cord (particularly in anterior regions); the T1- and T2-weighted images do not reflect this diffuse pathology.
